| 发明名称 | Myogenic differentiation of stem cells and uses thereof | ||
| 摘要 | Disclosed are methods of differentiating stem cells into muscle cells by growing the cells in a myogenic culture medium. The differentiated cells can be used as a source of cells for transplantation in a patient in need thereof. | ||
| 申请公布号 | US8900572(B2) | 申请公布日期 | 2014.12.02 |
| 申请号 | US201213523337 | 申请日期 | 2012.06.14 |
| 申请人 | Université Laval | 发明人 | Tremblay Jacques P.;Goudenege Sébastien;Huot Nicolas B.;Lebel Carl |
| 分类号 | A61K35/12;C12N5/077;A61K35/54 | 主分类号 | A61K35/12 |
| 代理机构 | Goudreau Gage Dubuc | 代理人 | Goudreau Gage Dubuc ;Shahinian S. Serge |
| 主权项 | 1. A method of inducing differentiation of human induced pluripotent stem cells (iPSCs) into myogenic cells comprising i) culturing said iPSCs in a myogenic differentiation medium to induce differentiation into mesenchymal-like cells expressing TBX1 and TBX4; and ii) culturing said mesenchymal-like cells in the presence of at least one myogenic factor to complete differentiation into myogenic cells. | ||
| 地址 | Québec CA | ||