Integration of sample storage and sample management for life science

摘要

Compositions and methods are disclosed for automated storing, tracking, retrieving and analyzing biological samples, including dry storage at ambient temperatures of nucleic acids, proteins (including enzymes), and cells using a dry storage matrix that permits recovery of biologically active materials. RFID-tagged biological sample storage devices featuring dissolvable or dissociable matrices are described for use as supports of biological samples, which matrices can be dried and subsequently rehydrated for sample recovery. Also disclosed are computer-implemented systems and methods for managing sample data.

主权项

1. A biological sample storage device for dry storage of one or a plurality of biological samples without refrigeration and lyophilization, comprising a sample plate comprising one or a plurality of sample wells for containing a biological sample, wherein one or more of said wells comprises a matrix material that dissolves in water; wherein the matrix comprises at least one stabilizer, wherein if the at least one stabilizer comprises a first stabilizer that is trehalose, then a trehalase inhibitor is also present as a second stabilizer; wherein the matrix is free of fibers and cellulosic materials; and wherein at least 50% of the biological sample is recovered from the matrix when a solvent is added to the matrix when the matrix has the biological sample stored therein without refrigeration and without lyophilization.