RHO KINASE INHIBITORS

摘要

Disclosed are novel substituted 2H-isoquinolin-1 -one and 3H-quinazolin-4-one derivatives useful as inhibitors of Rho kinase and for treating a variety of diseases and disorders that are mediated or sustained through the activity of Rho kinase, including cardiovascular diseases, pharmaceutical compositions comprising such compounds, methods for using such compounds and processes for making such compounds. The compounds are represented by formula (I): (see formula I)