Product and process for inhibition of biofilm development

摘要

Disclosed are compositions and methods for the inhibition of biofilm formation or reduction of existing or developing biofilms in a patient. These methods also inhibit the aggregation of bacteria that form biofilms in the airways. The methods include administering to a subject that has or is at risk of developing biofilms a compound or formulation that inhibits the formation or polymerization of actin microfilaments or depolymerizes actin microfilaments at or proximal to the site of biofilm formation. Such a compound can be administered in combination with a compound or formulation that inhibits the accumulation or activity of cells that are likely to undergo necrosis at or proximal to the site of biofilm formation (i.e., neutrophils). The methods and compositions can further include the use of anti-DNA and/or anti-mucin compounds, as well as other therapeutic compounds and compositions.

主权项

1. A method to reduce biofilms in a subject diagnosed as having biofilms, the biofilms forming as a result of the contact of the subject with a medical device, a graft, a catheter, a stent, a wound dressing, or a prosthesis; being associated with the presence of necrotic cells; and being produced by a microorganism that has enhanced biofilm formation in the presence of said necrotic cells, the method comprising administering to a subject that has biofilms, a compound that inhibits the formation or polymerization of actin microfilaments or depolymerizes actin microfilaments at or proximal to the site of biofilm formation or the site of infection by said microorganism wherein inhibition of the formation or polymerization of actin microfilaments or the depolymerization of actin filaments reduces biofilms in the subject, wherein the compound is selected from the group consisting of latrunculins and swinholides.