Binding partners for the thyrotropin receptor and uses thereof

摘要

A binding partner for the TSH receptor, which binding partner comprises, or is derived from, a human monoclonal or recombinant antibody, or one or more fragments thereof, reactive with the TSH receptor, uses thereof, methods of diagnosis and therapy employing the same, and anti-idiotypic antibodies thereto.

主权项

1. A kit for screening for autoantibodies to the TSH receptor or the presence of TSH or related ligands in a sample, said kit comprising:
(a) as a first component, means for binding to the TSH receptor, inhibiting binding to the TSH receptor and stimulating cyclic AMP production; and (b) a second component that exhibits a specific binding interaction with antibodies to TSH receptor, said second component comprising
(i) full length TSH receptor,(ii) an epitope of TSH receptor, or(iii) a polypeptide comprising one or more epitopes of a TSH receptor; wherein the first and second components are provided in the kit in packaged combination.