发明名称 |
Transdermal drug delivery system and method of using the same |
摘要 |
A transdermal drug delivery system comprising a steroid as an active agent, wherein the steroid may be clobetasol propionate, betamethasone dipropionate, amcinonide, or loteprednol etabonate. The transdermal drug delivery system also comprises a pressure-sensitive adhesive layer and a support, wherein the steroid is present in the pressure-sensitive adhesive layer, and wherein the pressure-sensitive adhesive layer is provided on a support. The transdermal drug delivery system may be applied onto the eyelid of a patient in need thereof, in order to treat a disease of the eyelid, such as chalazion, blepharitis or meibomian gland dysfunction. |
申请公布号 |
US8900626(B2) |
申请公布日期 |
2014.12.02 |
申请号 |
US201113164037 |
申请日期 |
2011.06.20 |
申请人 |
Senju USA, Inc. |
发明人 |
Ogawa Takahiro;Isowaki Akiharu |
分类号 |
A61F13/02;A61K31/56;A61K9/70;A61K9/00;A61K31/58;A61K31/573 |
主分类号 |
A61F13/02 |
代理机构 |
Wenderoth, Lind & Ponack, L.L.P. |
代理人 |
Wenderoth, Lind & Ponack, L.L.P. |
主权项 |
1. A transdermal drug delivery system for treatment of an eyelid disease comprising a pressure sensitive adhesive layer provided on a support,
wherein the pressure sensitive adhesive layer comprises a steroid and a pressure sensitive adhesive,
wherein the steroid is selected from the group consisting of clobetasol propionate, clobetasol butyrate, betamethasone dipropionate, amcinonide, and loteprednol etabonate,wherein the pressure-sensitive adhesive is selected from the group consisting of acrylic pressure sensitive adhesives, rubber-based pressure sensitive adhesives and silicone-based pressure sensitive adhesives,
wherein, if the pressure-sensitive adhesive is an acrylic pressure sensitive adhesive, the acrylic pressure sensitive adhesive is either
an alkyl (meth)acrylate-vinyl acetate copolymer oran acrylate-vinylacetate copolymer,wherein, if the pressure-sensitive adhesive is a rubber-based pressure sensitive adhesive, the rubber-based pressure sensitive adhesive is a styrene-isoprene-styrene block copolymer, wherein the transdermal drug delivery system has a shape capable of being applied along a skin surface of the upper eyelid, a skin surface of the lower eyelid, or a skin surface of both eyelids, and wherein the transdermal drug delivery system is capable of administering a therapeutically effective amount of the steroid to the eyelid with negligible irritation. |
地址 |
Woodland Hills CA US |