Absorbable polyurethanes and methods of use thereof

摘要

Disclosed are novel bioabsorbable and biodegradable monomer compounds, bioabsorbable and biodegradable polymers therefrom, and methods of making such monomers and polymers, which are useful in pharmaceutical delivery systems, tissue engineering applications, tissue adhesives products, implantable medical devices, foams and reticulated foams for wound healing and drug delivery, bone hemostats and bone void fillers, adhesion prevention barriers, meshes, filters, stents, medical device coatings, pharmaceutical drug formulations, consumer product and cosmetic and pharmaceutical packaging, apparel, infusion devices, blood collection tubes and devices, other medical tubes, skin care products, and transdermal drug delivery materials.

主权项

1. A diisocyanate or diamine compound having the structure of any of formulas (1), (2), (16) or (17): wherein each X represents a member independently selected from the group consisting of: —CH2COO— (glycolic acid moiety); —CH(CH3)COO— (lactic acid moiety); —CH2CH2OCH2COO— (dioxanone moiety); —CH2CH2CH2CH2CH2COO— (caprolactone moiety); —(CH2)yCOO— where y is one of the numbers 2, 3, 4 and 6-24 inclusive; and —(CH2CH2O)z′CH2COO— where z′ is an integer between 2 and 24, inclusive; wherein Rn represents one or more substituents selected from the group consisting of hydrogen, alkoxy, phenoxy, benzyloxy, —CHO, halogen, carboxylic acid and nitro, which are attached directly to the aromatic ring or indirectly via an alkylene chain; and wherein p is an integer between 1 and 4, inclusive.