Method for synthesizing 3,5-dichloroanisole from 1,3,5-trichlorobenzene

摘要

A method for synthesizing 3,5-dichloroanisole from 1,3,5-trichloro-benzene is proved. The method may comprises: a) the reaction between 1,3,5-trichloro-benzene and a methanolate of an alkaline or alkaline-earth metal in a first solvent chosen from among dimethylsulfoxide and 1,1,3,3-tétramethylurea, b) the precipitation of the product resulting from step a) in a second solvent which is not included among substances considered carcinogenic, mutagenic and/or toxic for reproduction by Regulation (EC) no 1272/2008 of the European Parliament and of the Council of 16 Dec. 2008, then c) the recovery of the precipitate thus obtained. The method may be applied to synthesize 1,3,5-triamino-2,4,6-trinitrobenzene in which 3,5-dichloroanisole is an intermediate product.

主权项

1. A method for synthesizing 3,5-dichloro-anisole from 1,3,5-trichlorobenzene, which comprises:
a) reacting 1,3,5-trichloro-benzene with a methanolate of an alkaline or alkaline-earth metal in a first solvent selected from the group consisting of dimethylsulfoxide, 1,1,3,3-tetramethylurea and mixtures thereof; b) precipitating the product resulting from a) in a second solvent which is water; then c) recovering the precipitate obtained in b).