| 主权项 |
1. A compound having the structure of:wherein:
R3 is selected from the group consisting of: H, alkyl, alkenyl, alkynyl, haloalkyl, heteroalkyl, cycloalkyl, heterocycloalkyl, aryl, heteroaryl, cycloalkylalkyl, heterocycloalkylalkyl, arylalkyl, heteroarylalkyl and acyl, each of which may be optionally substituted; R4 is selected from the group consisting of: H, alkyl, alkenyl, alkynyl, haloalkyl, heteroalkyl, cycloalkyl, heterocycloalkyl, aryl, heteroaryl, cycloalkylalkyl, heterocycloalkylalkyl, arylalkyl, heteroarylalkyl and acyl, each of which may be optionally substituted; Z is a single bond or is selected from —CH2—, —CH2CH2—, —CH═CH— and C3-C6 cycloalkyl, each of which may be optionally substituted; each Y is independently selected from the group consisting of: H, halogen, —CN, —NO2, —CF3, —OCF3, alkyl, alkenyl, alkynyl, haloalkyl, haloalkenyl, haloalkynyl, heteroalkyl, cycloalkyl, cycloalkenyl, heterocycloalkyl, heterocycloalkenyl, aryl, heteroaryl, hydroxy, hydroxyalkyl, alkoxy, alkoxyalkyl, alkoxyaryl, alkoxyheteroaryl, alkenyloxy, alkynyloxy, cycloalkyloxy, cycloalkenyloxy, heterocycloalkyloxy, heterocycloalkenyloxy, aryloxy, heteroaryloxy, arylalkyl, heteroarylalkyl, arylalkyloxy, amino, alkylamino, acylamino, aminoalkyl, arylamino, sulfonyl, alkylsulfonyl, arylsulfonyl, aminosulfonyl, aminoalkyl, alkoxyalky, —COOH—C(O)OR6, —COR6, —SH, —SR7, —OR7, acyl and —NR8R9 each of which may be optionally substituted; each R6 is independently selected from the group consisting of: H, alkyl, alkenyl, alkynyl, haloalkyl, heteroalkyl, cycloalkyl, heterocycloalkyl, aryl, heteroaryl, cycloalkylalkyl, heterocycloalkylalkyl, arylalkyl, heteroarylalkyl and acyl, each of which may be optionally substituted; each R7 is independently selected from the group consisting of: H, alkyl, alkenyl, alkynyl, haloalkyl, heteroalkyl, cycloalkyl, heterocycloalkyl, aryl, heteroaryl, cycloalkylalkyl, heterocycloalkylalkyl, arylalkyl, heteroarylalkyl and acyl, each of which may be optionally substituted; each R8 and R9 is independently selected from the group consisting of: H, alkyl, alkenyl, alkynyl, haloalkyl, heteroalkyl, cycloalkyl, heterocycloalkyl, aryl, heteroaryl, cycloalkylalkyl, heterocycloalkylalkyl, arylalkyl, heteroarylalkyl and acyl, each of which may be optionally substituted; p is an integer selected from the group consisting of 0, 1, 2, and 3; q is an integer from 0 to 5; L is selected from the group consisting of:
a) Cy-L1-W—b) Cy-L1-W-L2-;c) Cy-(CH2)k—W—;d) L1-W-L2-;e) Cy-L1-;f) R12—W1-L1-W—; andg) —(CR20R21)m—(CR22R23)n—(CR24R25)o—NR26R27; wherein Cy is selected from the group consisting of C1-C15 alkyl, aminoalkyl, heteroalkyl, heterocycloalkyl, cycloalkyl, aryl, aryloxy and heteroaryl, each of which may be optionally substituted; L1 is selected from the group consisting of a bond, C1-C5 alkyl and C2-C5 alkenyl, each of which may be optionally substituted; L2 is selected from the group consisting of C1-C5 alkyl and C2-C5 alkenyl, each of which may be optionally substituted; k is 0, 1, 2, 3, 4 or 5; W is selected from the group consisting of a bond, —O—, —S—, —S(O)—, —S(O)2—, —N(R10)—, —C(O)N(R10)—, —SO2N(R10)—, —N(R10)C(O)—, —N(R10)SO2—, —N(R10)C(O)N(R11)—, —C(O)N(R10)C(O)N(R11)— and —N(R10)C(O)N(R11)C(O)—; W1 is selected from the group consisting of a bond, —O—, —S—, —S(O)—, —S(O)2—, —N(R10)—, —C(O)N(R10)—, —SO2N(R10)—, —N(R10)C(O)—, —N(R10)SO2—, —N(R10)C(O)N(R11)—, —C(O)N(R10)C(O)N(R11)— and —N(R10)C(O)N(R11)C(O)—; each R10 and R11 is independently selected from the group consisting of: H, C1-C6 alkyl, C1-C6 alkenyl, C1-C10 heteroalkyl, C4-C9 cycloalkyl, C4-C9 heterocycloalkyl, aryl, heteroaryl, arylalkyl, and heteroarylalkyl and acyl, each of which may be optionally substituted; each R20, R21, R22, R23, R24 and R25 is independently selected from the group consisting of: H, halogen, —CN, —NO2, —CF3, —OCF3, alkyl, alkenyl, alkynyl, haloalkyl, haloalkenyl, haloalkynyl, heteroalkyl, cycloalkyl, cycloalkenyl, heterocycloalkyl, heterocycloalkenyl, aryl, heteroaryl, cycloalkylalkyl, heterocycloalkylalkyl, arylalkyl, heteroarylalkyl, arylalkenyl, cycloalkylheteroalkyl, heterocycloalkylheteroalkyl, heteroarylheteroalkyl, arylheteroalkyl, hydroxy, hydroxyalkyl, alkoxy, alkoxyalkyl, alkoxyaryl, alkoxyheteroaryl, alkenyloxy, alkynyloxy, cycloalkylkoxy, heterocycloalkyloxy, aryloxy, arylalkyloxy, phenoxy, benzyloxy heteroaryloxy, amino, alkylamino, acylamino, aminoalkyl, arylamino, alkoxycarbonyl, alkylaminocarbonyl, sulfonyl, alkylsulfonyl, aminosulfonyl, arylsulfonyl, arylsulfinyl —COOH, —C(O)OR5, —COR5, —SH, —SR6, —OR6 and acyl, each of which may be optionally substituted; or R20 and R21 when taken together may form a group of formula ═O or ═S, and/or R22 and R23 when taken together may form a group of formula ═O or ═S, and/or R24 and R25 when taken together may form a group of formula ═O or ═S; each R26 and R27 is independently selected from the group consisting of: H, halogen, alkyl, alkenyl, alkynyl, haloalkyl, haloalkenyl, heteroalkyl, cycloalkyl, cycloalkenyl, heterocycloalkyl, heterocycloalkenyl, aryl, heteroaryl, cycloalkylalkyl, heterocycloalkylalkyl, arylalkyl, heteroarylalkyl, arylalkenyl, cycloalkylheteroalkyl, heterocycloalkylheteroalkyl, heteroarylheteroalkyl, arylheteroalkyl, hydroxy, hydroxyalkyl, alkoxy, alkoxyalkyl, alkoxyaryl, alkenyloxy, alkynyloxy, cycloalkylkoxy, heterocycloalkyloxy, aryloxy, arylalkyloxy, heteroaryloxy, amino, alkylamino, aminoalkyl, acylamino, arylamino, phenoxy, benzyloxy, COOH, alkoxycarbonyl, alkylaminocarbonyl, sulfonyl, alkylsulfonyl, alkylsulfinyl, arylsulfonyl, arylsulfinyl, aminosulfonyl, SR5, acyl and G, each of which may be optionally substituted, or R26 and R27 when taken together with the nitrogen atom to which they are attached form a heterocycloalkyl or heteroaryl group, each of which may be optionally substituted; m, n and o are each integers that are independently selected from the group consisting of 0, 1, 2, 3 and 4; and G is a group of formula: -L3W3 wherein L3 is selected from the group consisting of C1-C5 alkyl and C2-C5 alkenyl, each of which may be optionally substituted; W3 is selected from the group consisting of —OR12, —SR12, —S(O)R12, —S(O)2R12, —N(R12)2, —C(O)N(R12)2, —SO2N(R12)2, —NR12C(O)—, —NR12SO2R12, —NR12C(O)N(R12)2, —C(O)NR12C(O)N(R12)2 and —N(R12)C(O)N(R12)C(O)R12; and each R12 is independently selected from the group consisting H, halogen, —CN, —NO2, —CF3, —OCF3, alkyl, alkenyl, alkynyl, haloalkyl, haloalkenyl, heteroalkyl, cycloalkyl, cycloalkenyl, heterocycloalkyl, heterocycloalkenyl, aryl, heteroaryl, cycloalkylalkyl, heterocycloalkylalkyl, arylalkyl, heteroarylalkyl, arylalkenyl, cycloalkylheteroalkyl, arylheteroalkyl, heterocycloalkylheteroalkyl, heteroarylheteroalkyl, hydroxy, hydroxyalkyl, alkoxy, alkoxyalkyl, alkoxyaryl, alkenyloxy, alkynyloxy, cycloalkylkoxy, heterocycloalkyloxy, aryloxy, heteroaryloxy, arylalkyloxy, phenoxy, benzyloxy, amino, alkylamino, aminoalkyl, acylamino, arylamino, sulfonylamino, sulfinylamino, —COOH, —COR6, —COOR5, —CONHR5, —NHCOR5, —NHCOOR5, —NHCONHR5, C(═NOH)R5, -alkylNCOR5, alkoxycarbonyl, alkylaminocarbonyl, sulfonyl, alkylsulfonyl, alkylsulfinyl, arylsulfonyl, arylsulfinyl, aminosulfonyl, SR6 and acyl, each of which may optionally be substituted;or a pharmaceutically acceptable salt thereof. |
