| 摘要 |
There is provided a novel carbamoyloxy arylalkanoyl arylpiperazine derivative compound having abundant racemic or enantiomeric characteristics, represented by the Formula 1, and pharmaceutically available salts or hydrates thereof. Also, there are provided a pharmaceutical composition for treating pain, anxiety or depression including an effective amount of the compound, and a method for treating pain, anxiety or depression in mammals by administering an effective amount of the compound to the mammals in need of treatment thereof. |
| 主权项 |
1. A method for treating pain, anxiety or depression, comprising:
administering to a patient in need of treatment thereof a therapeutically effective amount of a compound of Formula 1: or a pharmaceutically acceptable salt or hydrate thereof, wherein - - - denotes an optional bond forming a cyclic moiety; each of R1 and R2 is independently selected from the group consisting of H- and straight- or branched-chain C1-C6 alkyl, or R1 and R2 are taken together to form piperidinyl or piperazinyl, or R1 and R2 are taken together with Ar1 to form benzo[d][1,3]oxazin-2-one moiety; Ar1 is selected from the group consisting of furanyl, methylenedioxyphenyl and phenyl which is optionally substituted by one or more substituents independently selected from the group consisting of H-, straight- or branched-chain C1-C6 alkyl, fluoro, chloro, bromo, straight- or branched-chain C1-C6 alkoxy, nitro and trifluoromethyl; z is H— or fluoro; Ar2 is selected from the group consisting of phenyl, methylenedioxyphenyl, pyridinyl, pyrimidinyl, naphthyl, and quinoxalinyl, wherein Ar2 is optionally substituted by one or more substituents independently selected from the group consisting of H-, straight- or branched-chain C1-C6 alkyl, hydroxy, halo, straight- or branched-chain C1-C6 alkoxy, nitro, acetyl, t-butylacetyl, trifluoromethyl, amino and acetyloxy; n is 1 or 2; and m is 0, 1 or 2. |
