TREATMENT OF METASTATIC BREAST CANCER

摘要

THE PRESENT INVENTION CONCERNS TREATMENT OF PREVIOUSLY UNTREATED HER2-POSITIVE METASTATIC BREAST CANCER WITH A COMBINATION OF A GROWTH INHIBITORY HER2 ANTIBODY, A HER2 DIMERIZATION INHIBITOR ANTIBODY AND A TAXANE. IN PARTICULAR, THE INVENTION CONCERNS THE TREATMENT OF HER2-POSITIV METASTATIC BREAST CANCER IN PATIENTS WHO DID NOT RECEIVE PRIOR CHEMOTHERAPY OR BIOLOGIC THERAPY WITH A HER2 ANTIBODY BINDING ESSENTIALLY TO EPITOPE 2C4, A HER2 ANTIBODY BINDING ESSENTIALLY TO EPITOPE 4D5, AND A TAXANE. THE INVENTION FURTHER COMPRISES EXTENDING SURVIVAL OF SUCH PATIENTS BY THE COMBINATION THERAPY OF THE PRESENT INVENTION. IN A PREFERRED EMBODIMENT, THE TREATMENT INVOLVES ADMINISTRATION OF TRASTUZUMAB, PERTUZUMAB AND DOCETAXEL.