Process of producing cycloalkylcarboxamido-indole compounds

摘要

Disclosed herein is a method for preparing cycloalkylcarboxamido-indole compounds which are useful for treating CFTR mediated diseases such as cystic fibrosis. In particular a method of preparing a compound of formula I comprising the steps of: Reacting a compound of formula IA in a first organic solvent with a compound of formula IB; to form a compound of formula IC in the presence of a palladium catalyst; and Removing the–CO2RJ group from compound IC in a second organic solvent to form the compound of formula I.