Methods and compositions for diagnosis and prognosis of renal injury and renal failure

摘要

Disclosed is an ex vivo method for evaluating renal status in a subject, said method comprising detecting Antileukoproteinase (SLPI) and Thrombomodulin (CD41) in a sample, determining the concentration of Thrombomodulin and Antileukoproteinase and determining the renal status according to the specific methods as described herein. Further disclosed is the combined use of antibodies or antibody fragments in a method performed ex vivo on one or more body fluid samples obtained previously from a subject in determining a present or future reduced renal function in the subject, wherein the antibodies or antibody fragments bind independently to: (i) Thrombomodulin or an epitope thereof; and (ii) Antileukoproteinase or an epitope thereof.