Inhibitors of nicotinamide phosphoribosyltransferase and therapeutic uses thereof

摘要

The disclosure relates to compounds, pharmaceutical compositions and methods useful for treating cancer, systemic or chronic inflammation, rheumatoid arthritis, diabetes, obesity, T-cell mediated autoimmune disease, ischemia, and other complications associated with these diseases and disorders. Compounds of the invention include: 3’-[(methylsulfonyl)amino]-N-(4-{ [(pyridin-3-ylmethyl)carbamoyl]amino} phenyl)biphenyl-2-sulfonamide, 1-(4-{ [2-(4-Chloropyridin-3-yl)benzyl]oxy} phenyl)-3-(pyridin-3-ylmethyl)urea, 1-{ 4-[(Biphenyl-2-ylmethyl)(ethyl)amino]phenyl} -3-(pyridin-3-ylmethyl)urea and 3’-[(4-Methylpiperazin-1-yl)methyl]-N-(4-{ [(pyridin-3-ylmethyl)carbamoyl]amino} phenyl)biphenyl-2-sulfonamide.