| 摘要 |
The invention relates to a process of purification of 1-[2-(2,4-dimethylphenylsulfanyl)phenyl]piperazine-HBr, comprising the steps of: a) obtaining a solution by dissolving 1-[2-(2,4-dimethylphenylsulfanyl)phenyl] piperazine-HBr in a solvent comprising more than 65% (v/v) isopropanol; b) precipitating 1-[2-(2,4-dimethylphenylsulfanyl)phenyl]piperazine-HBr isopropanol solvate from said achieved solution; c) dissolving 1-[2-(2,4-dimethylphenylsulfanyl)phenyl]piperazine-HBr isopropanol solvate in a non-solvate forming solvent; and d) precipitating 1-[2-(2,4-dimethylphenylsulfanyl)phenyl]piperazine-HBr from the solution obtained in c). The present invention also relates to a novel compound which is 1-[2-(2,4-dimethylphenylsulfanyl)phenyl]piperazine-HBr isopropanol solvate, the compound has XRPD reflections at approximately 6.44, 8.13, 8.77, 10.41 (°2Θ), having an XRPD as depicted in fig. 2. |
