| 摘要 |
<p>Disclosed herein are sinomenine derivatives of formula (I), wherein the variables are as defined in the specification. Also disclosed is a process encompassing synthetic routes for the production of (+)-sinomenine derivatives and their intermediates. Sinomenine is an alkaloid isolated from the root of Sinomenium acutum, which is reported to possess anti-inflammatory, analgesic, blood pressure lowering, and anti-arrhythmia activities. Both the isolated molecule and the S. acutum plant have been used clinically in China for the treatment of rheumatoid arthritis.</p> |
