AQUEOUS OPHTHALMIC SUSPENSION OF CRYSTALLINE REBAMIPIDE

摘要

THE INVENTION PROVIDES AN OPHTHALMIC PRODUCT CONTAINING REBAMIPIDE, WHICH HAS A TRANSPARENCY ENOUGH TO BE AGREEABLE FEELING ON USING IT AND HAS NEUTRAL TO WEAKLY ACIDIC PH NOT TO INJURY OF THE KERATOCONJUNCTIVA OF A PATIENT SUFFERING FROM DRY EYE. AN AQUEOUS SUSPENSION OF CRYSTALLINE REBAMIPIDE WHICH HAS AN IMPROVED TRANSPARENCY IS PROVIDED BY ADDING AN AQUEOUS SOLUTION OF REBAMIPIDE DISSOLVED BY A BASE SUCH AS SODIUM HYDROXIDE OR AN AQUEOUS SOLUTION OF A SALT OF REBAMIPIDE TO AN AQUEOUS ACIDIC SOLUTION SUCH AS HYDROCHLORIC ACID CONTAINING AT LEAST ONE OF THE COMPOUNDS SELECTED FROM WATER-SOLUBLE POLYMERS AND SURFACTANTS, AND MIXING THEM.