Reversible oral adhesive gel

摘要

The disclosure relates to a reversible oral adhesive gel for securing lips together, the reversible oral adhesive gel comprising: one or more adhesive agents, the oral adhesive in the form of a gel and having a pH of 5.0 or lower, and wherein the adhesive agent or agents are selected from the group consisting of: an alkyl vinyl ether/maleic anhydride copolymer, mixed sodium/calcium salts of methyl vinyl ether/maleic anhydride copolymer and soluble polyvinyl pyrrolidones; and one or more thickener/hydrophobic gelling agents in an amount from about 1wt% to about 10wt%, the one or more thickener/hydrophobic gelling agents selected from the group consisting of xanthan gum, carageenan gum, guar gum, sodium alginate, acacia gum, hydroxypropylcellulose, hydroxypropylmethylcellulose, gelatin, and pectin; wherein the reversible oral adhesive gel has an average maximum stress value of at least 0.01 MPa. Also disclosed is a method of preparing a reversible oral adhesive gel, comprising the steps of: (a) mixing 1.0 gm of disodium edetate, 2.0 gm of potassium sorbate and 20.0 gm of citric acid anhydrous in 547.0 gm of purified water for 10 min at 25°C; (b) adding to the mixture of step (a) 120.0 gm of a calcium/sodium PVM/MA copolymer, avoiding lump formation and mixing until fully dispersed; (c) adding to the mixture of step (b) 100.0 gm of ethanol 95% undenatured, mixing until fully dispersed; (d) adding to the mixture of step (c) 120.0 gm of a soluble polyvinyl pyrrolidone avoiding lump formation and mixing until fully dispersed; (e) adding to the mixture of step (d) 20.0 gm of xanthum gum, avoiding lump formation and mixing until fully dispersed; (f) adding to the mixture of step (e) 45.0 gm of silicon fluid, avoiding lump formation and mixing until fully dispersed; (g) adding to the mixture of step (f) 10.0 gm of silicon dioxide, avoiding lump formation and mixing fully until dispersed; and (h) adding to the mixture of step (g) 15.0 of a polyacrylamide, C13-C14 isoparaffin and Laureth-7 mixture, avoiding lump formation and mixing until fully dispersed thereby forming said reversible oral adhesive gel.