发明名称 |
SITE-SPECIFIC INCORPORATION OF AMINO ACIDS INTO MOLECULES |
摘要 |
<p>The invention provides certain embodiments relating to methods and compositions for incorporating non-natural amino acids into a polypeptide or protein by utilizing a mutant or modified aminoacyl-tRNA synthetase to charge the non-natural amino acid to a the corresponding tRNA. In certain embodiments, the tRNA is also modified such that the complex forms strict Watson-Crick base-pairing with a codon that normally forms wobble base-pairing with unmodified tRNA/aminoacyl-tRNA synthetase pairs.</p> |
申请公布号 |
SI1999259(T1) |
申请公布日期 |
2014.11.28 |
申请号 |
SI20070031519T |
申请日期 |
2007.03.05 |
申请人 |
CALIFORNIA INSTITUTE OF TECHNOLOGY |
发明人 |
WANG PIN;KWON INCHAN;SON SOOJIN;TANG YI;TIRRELL DAVID A. |
分类号 |
|
主分类号 |
|
代理机构 |
|
代理人 |
|
主权项 |
|
地址 |
|