1,3-oxazines as bace1 and/or bace2 inhibitors

摘要

The present invention provides compounds of formula I having BACE1 and/or BACE2 inhibitory activity, their manufacture, pharmaceutical compositions containing them and their use as therapeutically active substances. The active compounds of the present invention are useful in the therapeutic and/or prophylactic treatment of e.g. Alzheimer’s disease and type 2 diabetes. Examples of the compounds for formula (I) are: (S)-4-{ S-[(4-Chloro-l-difluoromethyl-lH-pyrazol-3-ylmethyl)-amino ]-2-fluoro-phenyl } -4-methyl-S,6-dihydro-4H-[1,3]oxazin-2-ylamine (4R,SR)-4-[S-(Cyclopropylmethyl-amino)-2-fluoro-phenyl]-S-fluoro-4-methyl-S,6-dihydro-4H[1,3]oxazin-2-ylamine 7-[3-((R)-2-Amino-5,5-difluoro-4-methyl-5,6-dihydro-4H-[1,3]oxazin-4-yl)-4-fluorophenylamino]-6,7-dihydro-5H-[1]pyrindine-3-carbonitrile.