发明名称 |
ASSOCIATING SOMATIC GENE MUTATIONS IN GLYCOPHORIN A WITH COMPLEX MULTIFACTORIAL DISEASES |
摘要 |
In the detection of a complex multifactorial disease, an MN blood group typing is performed on a first blood sample of a subject to be tested for a complex multifactorial disease, and on a second blood sample of a control subject having known phenotypes. Erythrocytes from the samples are isovolumetrically sphered, and M alleles and N alleles expressed on surfaces of erythrocyte cells of the first and second blood samples are labeled by contacting the blood samples with anti-M antibodies and anti-N antibodies associated with a marker. Labeled M alleles and labeled N alleles in the first and second blood samples are detected and quantified using the marker, in order to determine an incidence of somatic mutations in Glycophorin A of the patient. The incidence is compared with data pertaining to patients with a known complex multifactorial disease, to diagnose the patient. |
申请公布号 |
WO2014190358(A1) |
申请公布日期 |
2014.11.27 |
申请号 |
WO2014US39626 |
申请日期 |
2014.05.27 |
申请人 |
NOVA SOUTHEASTERN UNIVERSITY |
发明人 |
GRANT, STEPHEN, G.;LATIMER, JEAN, J. |
分类号 |
G01N33/80 |
主分类号 |
G01N33/80 |
代理机构 |
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