GENETIC TEST FOR LIVER COPPER ACCUMULATION IN DOGS

摘要

The present invention provides a method of testing a dog to determine the susceptibility of the dog to liver copper accumulation, comprising detecting in a sample the presence or absence in the genome of the dog of one or more polymorphisms selected from: (a) Chr22_3167534 (SEQ ID NO: 144), Chr22_3135144 (SEQ ID NO: 145), Chr20_55461150 (SEQ ID NO: 146), ChrX_120879711 (SEQ ID NO: 147), Chr19_6078084 (SEQ ID NO: 148), Chr15_62625262 (SEQ ID NO: 149), Chr14_39437543 (SEQ ID NO: 150), Chr15_62625024 (SEQ ID NO: 151), Chr3_86838677 (SEQ ID NO: 152), Chr24_4011833 (SEQ ID NO: 153), Chr18_60812198 (SEQ ID NO: 154), Chr10_65209946 (SEQ ID NO: 155), and the CGCCCC repeat at chromosome location 22:3135287; (b) one or more polymorphisms in linkage disequilibrium with a said polymorphism (a); and/or (c) Chr32_38904515 (SEQ ID NO: 156), Chr8_4892743 (SEQ ID NO: 157) and Chr8_4880518 (SEQ ID NO: 158).

主权项

1. A method of testing a dog to determine the susceptibility of the dog to liver copper accumulation, comprising detecting in a sample the presence or absence in the genome of the dog of one or more polymorphisms selected from:
(a) Chr22—3167534 (SEQ ID NO: 144), Chr22—3135144 (SEQ ID NO: 145), Chr20—55461150 (SEQ ID NO: 146), ChrX—120879711 (SEQ ID NO: 147), Chr19—6078084 (SEQ ID NO: 148), Chr15—62625262 (SEQ ID NO: 149), Chr14—39437543 (SEQ ID NO: 150), Chr15—62625024 (SEQ ID NO: 151), Chr3—86838677 (SEQ ID NO: 152), Chr24—4011833 (SEQ ID NO: 153), Chr18—60812198 (SEQ ID NO: 154), Chr10—65209946 (SEQ ID NO: 155), and the CGCCCC repeat at chromosome location 22:3135287; (b) one or more polymorphisms in linkage disequilibrium with a said polymorphism (a); and/or (c) Chr32—38904515 (SEQ ID NO: 156), Chr8—4892743 (SEQ ID NO: 157) and Chr8—4880518 (SEQ ID NO: 158).