IL-1 BINDING PROTEINS

摘要

Proteins that bind IL-1α and IL-1β are described along with their use in compositions and methods for treating, preventing, and diagnosing IL-1-related disorders and for detecting IL-1α and IL-1β in cells, tissues, samples, and compositions.

主权项

1. An isolated composition comprising an anti-IL-1α/β dual variable domain immunoglobulin, or antigen-binding portion thereof, wherein, when administered intravenously to a subject at a dose of about 5 mg/kg, the anti-IL-1α/β dual variable domain immunoglobulin, or antigen-binding portion thereof, exhibits:
(a) an area under the curve (AUC) of between about 15 and 25 mgh/ml; (b) a volume of distribution of between about 85 and 105 mL/kg; (c) a half-life of between about 7 and about 13 days; or (d) a clearance rate of between about 0.1 and about 0.4 ml/h/kg.