INHIBITION OF SECRETION FROM NON-NEURONAL CELLS

摘要

The present invention relates to treatment of disease by inhibition of cellular secretory processes, to agents and compositions therefor, and to manufacture of those agents and compositions. The present invention relates particularly, to treatment of disease dependent upon the exocytotic activity of endocrine cells, exocrine cells, inflammatory cells, cells of the immune system, cells of the cardiovascular system and bone cells.

主权项

1. A method of suppressing hypersecretion from an endocrine cell in a patient in need thereof, said method comprising:
administering an effective amount of a modified clostridial neurotoxin to said patient; wherein the modified clostridial neurotoxin comprises a clostridial toxin light chain and a clostridial toxin translocation domain in which the neuronal targeting activity of the clostridial neurotoxin has been removed; and wherein said modified clostridial neurotoxin is covalently linked to a ligand that binds to a receptor present on said endocrine cell; wherein upon binding of the ligand to the receptor, the light chain is translocated into the cytosol of the cell by the translocation domain and cleaves one or more SNARE proteins essential to exocytosis in the cell.