发明名称 |
VARIANT ACTIVIN RECEPTOR POLYPEPTIDES, ALONE OR IN COMBINATION WITH CHEMOTHERAPY, AND USES THEREOF |
摘要 |
The present invention provides variant activin IIB soluble receptor polypeptides and proteins capable of binding and inhibiting the activities of activin A, myostatin, or GDF-11. The present invention also provides polynucleotides, vectors and host cells capable of producing the variant polypeptides and proteins. Compositions and methods for treating muscle-wasting and other diseases and disorders are also provided. |
申请公布号 |
US2014348827(A1) |
申请公布日期 |
2014.11.27 |
申请号 |
US201214366978 |
申请日期 |
2012.12.19 |
申请人 |
Amgen Inc. |
发明人 |
Sun Jeonghoon;Tam Lei-Ting Tony;Han Huiquan;Kwak Keith Soo-Nyung;Zhou Xiaolan |
分类号 |
A61K38/17;A61K39/395;A61K31/4164;A61K45/06;A61K31/7072 |
主分类号 |
A61K38/17 |
代理机构 |
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代理人 |
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主权项 |
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地址 |
Thousand Oaks CA US |