| 发明名称 |
CHIMERIC THERAPEUTIC ANTI - CD37 ANTIBODIE HH1 |
| 摘要 |
The present invention relates to chimieric or humanized antibodies derived from the mouse monoclonal antibody HH1. The applications of the present invention include therapeutic applications in which pharmaceutical compositions comprising the antibodies of the present invention or radioimmunoconjugates hereof are used for treating B-cell malignancies. |
| 申请公布号 |
US2014348745(A1) |
申请公布日期 |
2014.11.27 |
| 申请号 |
US201214364620 |
申请日期 |
2012.12.12 |
| 申请人 |
Nordic Nanovector AS |
发明人 |
Larsen Roy H.;Dahle Jostein |
| 分类号 |
C07K16/28;A61K51/10 |
主分类号 |
C07K16/28 |
| 代理机构 |
|
代理人 |
|
| 主权项 |
1. An antibody that binds to human CD37 and that is derived from:
a) a murine monoclonal antibody that is defined by:
i) a variable heavy chain comprising the amino acid sequence shown in SEQ ID NO: 1; andii) a variable light chain comprising the amino acid sequence shown in SEQ ID NO:3, or from b) a non-human antibody recognizing the same epitope of human CD37 as the antibody defined in a) or recognizing an epitope that overlaps with said epitope; wherein said antibody is a chimeric or a humanized antibody. |
| 地址 |
Oslo NO |
