发明名称 |
Novel oxysterol analogue, Oxy149, induces osteogenesis and hedgehog signaling and inhibits adipogenesis |
摘要 |
<p>This invention relates, e.g., to a synthetic compound, Oxy149, having the structure (Formula I) or a bioactive or pharmaceutical composition comprising Oxy149 and a pharmaceutically acceptable carrier. Methods are also disclosed for using the compound or bioactive or pharmaceutical composition to treat a variety of disorders, including e.g. bone disorders, obesity, cardiovascular disorders, and neurological disorders. Oxy149 can be delivered either locally or systemically.</p> |
申请公布号 |
AU2013260057(A1) |
申请公布日期 |
2014.11.27 |
申请号 |
AU20130260057 |
申请日期 |
2013.03.15 |
申请人 |
THE REGENTS OF THE UNIVERSITY OF CALIFORNIA;UNIVERSITY OF LOUISVILLE RESEARCH FOUNDATION, INC. |
发明人 |
PARHAMI, FARHAD;JUNG, MICHAEL E.;STAPPENBECK, FRANK;PIERCE JR., WILLIAM M.;TAYLOR, K. GRANT;MERTEN, KEVYN E. |
分类号 |
C07J9/00;A61K31/575;A61P19/08 |
主分类号 |
C07J9/00 |
代理机构 |
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代理人 |
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主权项 |
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地址 |
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