METHOD AND COMPOSITION FOR PRODUCING ACTIVE VITAMIN K-DEPENDENT PROTEIN

摘要

PROBLEM TO BE SOLVED: To provide a method for producing an active vitamin K-dependent protein.SOLUTION: There is provided a method for increasing the quantity of a carboxylated vitamin K-dependent protein in a cell including a step to introduce a second heterologous nucleic acid encoding vitamin K epoxide reductase (VKOR) into a cell expressing a first nucleic acid encoding a vitamin K-dependent protein under a condition to express the first nucleic acid and the second nucleic acid and produce the vitamin K-dependent protein and VKOR.