| 主权项 |
1. A method for dispersing or killing a biofilm, the method comprising a step of treating the biofilm with an anti-biofilm composition, thereby effectively dispersing or killing the biofilm;
wherein the anti-biofilm composition comprises a biocidal polyamine compound selected from the group consisting of:and a salt thereof;
wherein: each Ra is a member independently selected from the group consisting of A1, A2, A3, A4, A5, A6, A7, A8, and A9 are each an An member independently selected selected from the group consisting of N, CRa, and CR5; or, alternatively, a pair of adjacent An members join to form a cycloalkyl, aryl, heterocyclyl, or heterocycloaryl ring; wherein at least one Ai member and at most five An members are an independently selected CRa; each R1a, R1b, R1c, and R1d is a member independently selected from the group consisting of hydrogen, fluoro, alkyl, and fluoroalkyl; or, alternatively, an R1a and an R1b join to form an oxo group; each R2a, R2b, R2c, R2d, R2e, and R2f is a member independently selected from the group consisting of hydrogen, alkyl, fluoroalkyl, alkenyl, alkynyl, aryl, heteroaryl, arylalkyl, or heteroarylalkyl; alternatively, a pair of R2 members from the same Ra group independently selected from the group R2a and R2b, R2c and R2d, and R2e and R2f join to form a member independently selected from the group consisting of spirocycloalkyl, spiroheterocycyl, and oxo; or, alternatively, an R2a and an R2c from the same Ra group join to form a ring independently selected from the group consisting of cycloalkyl and heterocycyl; each Rm is a member independently selected from the group consisting of —CR2aR2b—, —CR2cR2d—, —C(R2a)═(R2b)—, —CC—, and —C(R2a)(R2b)-L2-C(R2c)(R2d)—; each m is an integer independently selected from 1 to 20; each L1 and L2 is a member independently selected from the group consisting of a bond, —O—, —C(O)O—, —NR4—, —NR4C(O)—, and —C(O)NR4—; each R3 is a member independently selected from the group consisting of —Z1—R4, —Z1—Y1—R4, —Z1—Y1—Y2—R4, and —Z1—Y1—Y2—Y3—R4; each R4 is a member independently selected from the group consisting of hydrogen, alkyl, fluoroalkyl, alkenyl, alkynyl, aryl, heteroaryl, arylalkyl, and heteroarylalkyl; or, alternatively, for a —N(R4)2 group, one of the two R4 in the group is a member selected from the group consisting of —(CO)OR6a—, (CO)N(R6a)(R6b), and C(NR6a)N(R6b)(R6c); each R5 is a member independently selected from the group consisting of hydrogen, alkyl, hydroxyl, alkoxy, alkylamino, alkenyl, alkynyl, aryl, aryloxy, arylamino, cycloalkyl, cycloalkoxy, cycloalkylamino, heterocyclyl, heterocycyloxy, heterocycylamino, halo, haloalkyl, fluoroalkyloxy, heteroaryl, heteroaryloxy, heteroarylamino, arylalkyl, arylalkyloxy, arylalkylamino, heteroarylalkyl, heteroarylalkyloxy, heteroarylalkylamino; hydroxyalkyl, aminoalkyl, and alkylaminoalkyl; each Y1, Y2, and Y3 is an independently selected group of Formula IA: each Z1 and Z2 is a member independently selected from the group consisting of NR4 and O; and each R6a, R6b, and R6c is a member independently selected from the group consisting of hydrogen, alkyl, fluoroalkyl, alkenyl, alkynyl, aryl, heteroaryl, arylalkyl, cycloalkyl, and heteroarylalkyl; or, alternatively, two R6n members R6a and R6b or R6a and R6c form a heterocycyl ring; wherein the biocidal polyamine compound comprises at least two primary or secondary amino groups. |
