CHAPERONE-BASED INTEGRIN INHIBITORS FOR THE TREATMENT OF CANCER AND INFLAMMATORY DISEASES

摘要

The present disclosure provides isolated integrin αL polypeptides, such as α7 helix polypeptides from the alpha I domain of integrin. Such polypeptides inhibit the interaction between integrin and gp96, thereby inhibiting gp96 activity. Such inhibition can be used to prevent cancer cell growth, cancer metastasis and/or inflammation.

主权项

1. An isolated polypeptide comprising the α7 helix peptide domain from integrin or a sequence having 1 or 2 amino acid substitutions, deletions or insertions relative to the α7 helix peptide domain, wherein the polypeptide is not a full length integrin polypeptide.