| 发明名称 |
PROCESS FOR MODIFYING THE SURFACE MORPHOLOGY OF A MEDICAL DEVICE |
| 摘要 |
The present invention relates to a process for modifying the surface morphology of a medical device. The modified surface has, among other advantageous properties, an improved capacity for sorption or conjugation of a variety of bioactive agents, the addition of which will turn the medical device into a localized drug delivery system. |
| 申请公布号 |
US2014350680(A1) |
申请公布日期 |
2014.11.27 |
| 申请号 |
US201214367870 |
申请日期 |
2012.12.22 |
| 申请人 |
Le Dang Quang Svend;Chen Muwan;Chen Menglin;Baatrup Anette Overgaard;Bünger Cody Eric;Lysdahl Helle;Kjems Jørgen;Andersen Morten Østergaard;Besenbacher Flemming |
发明人 |
Le Dang Quang Svend;Chen Muwan;Chen Menglin;Baatrup Anette Overgaard;Bünger Cody Eric;Lysdahl Helle;Kjems Jørgen;Andersen Morten Østergaard;Besenbacher Flemming |
| 分类号 |
A61L27/14;A61F2/10;A61F2/28 |
主分类号 |
A61L27/14 |
| 代理机构 |
|
代理人 |
|
| 主权项 |
1. A method for modifying a surface morphology of a medical device comprising:
a) providing a medical device comprising a bulk part and a surface region, wherein said surface region comprises a biocompatible polymeric composition comprising a biocompatible polymer; b) contacting at least a portion of the biocompatible polymeric composition in said surface region with a solvent of the biocompatible polymer to form a first surface region film on at least a first part of said surface region; c) contacting at least a part of said first surface region film with a non-solvent of said biocompatible polymer, thereby forming a first solidified surface region film on at least a part of said surface region; and d) subjecting the first solidified surface region film to a hydrolytic treatment. |
| 地址 |
Aarhus C DK |
