发明名称 RING-FUSED PYRIMIDINES AND TRIAZINES AND USE THEREOF FOR THE TREATMENT AND/OR PROPHYLAXIS OF CARDIOVASCULAR DISEASES
摘要 The present application relates to novel fused pyrimidines and triazines, to processes for their preparation, to their use alone or in combinations for the treatment and/or prophylaxis of diseases and to their use for preparing medicaments for the treatment and/or prophylaxis of diseases, in particular for the treatment and/or prophylaxis of cardiovascular disorders.
申请公布号 US2014350020(A1) 申请公布日期 2014.11.27
申请号 US201113806425 申请日期 2011.07.05
申请人 Follmann Markus;Stasch Johannes-Peter;Redlich Gorden;Ackerstaff Jens;Griebenow Nils;Knorr Andreas;Wunder Frank;Li Volkhart Min-Jian;Kroh Walter;Bärfacker Lars 发明人 Follmann Markus;Stasch Johannes-Peter;Redlich Gorden;Ackerstaff Jens;Griebenow Nils;Knorr Andreas;Wunder Frank;Li Volkhart Min-Jian;Kroh Walter;Bärfacker Lars
分类号 C07D471/04;A61K31/53;C07D491/107;A61K31/527;A61K31/519;A61K45/06 主分类号 C07D471/04
代理机构 代理人
主权项 1. A compound of formula (I) in which A represents nitrogen or CR3, whereR3 represents hydrogen, deuterium, fluorine, difluoromethyl, trifluoromethyl, (C1-C4)-alkyl, cyclopropyl or cyclobutyl, L represents a group *—CR4AR4B—(CR5AR5B)p-#, where* represents the point of attachment to the carbonyl group,# represents the point of attachment to the pyrimidine or triazine ring,p represents a number 0, 1 or 2,R4A represents hydrogen, fluorine, (C1-C4)-alkyl or hydroxyl,R4B represents hydrogen, fluorine, (C1-C4)-alkyl, trifluoromethyl, (C1-C4)-alkoxy-carbonylamino or phenyl, where (C1-C4)-alkyl may be substituted by 1 or 2 substituents independently of one another selected from the group consisting of fluorine, trifluoromethyl, hydroxyl, hydroxycarbonyl and (C1-C4)-alkoxycarbonyl,orR4A and R4B together with the carbon atom to which they are attached form an oxo group, a 3- to 6-membered carbocycle or a 4- to 6-membered heterocycle, where the 3- to 6-membered carbocycle and the 4- to 6-membered heterocycle may be substituted by 1 or 2 substituents independently of one another selected from the group consisting of fluorine and (C1-C4)-alkyl,orR4A and R4B together with the carbon atom to which they are attached form a (C2-C4)-alkenyl group,R5A represents hydrogen, fluorine, (C1-C4)-alkyl or hydroxyl,R5B represents hydrogen, fluorine, (C1-C4)-alkyl or trifluoromethyl, R1 represents hydrogen or fluorine, R2 represents benzyl, where benzyl is substituted by 1 to 3 fluorine substituents, or an N-oxide, salt, solvate, salt of the N-oxide, or and solvate of the N-oxide or salt thereof.
地址 Koln DE