Using Adaptive Immunity to Detect Drug Resistance

摘要

The present invention relates to a method of using adaptive immunity to detect drug resistance in infectious diseases. The invention provides novel antigens associated with drug resistant MTB infection.

主权项

1. A method of assessing microbial infection in a mammal, the method comprising:
a) contacting at least one polypeptide that is differentially expressed in a drug-resistant strain compared to a corresponding drug-susceptible strain with a biological sample from the mammal; and b) measuring an immune response in the biological sample, wherein an increase in the immune response to the at least one polypeptide that is differentially expressed in a drug-resistant strain compared to a corresponding drug-susceptible strain in the biological sample of the mammal indicates a past or present microbial infection with a drug-resistant strain.