| 发明名称 |
BETA-MANNOSYLCERAMIDE AND STIMULATION OF NKT CELL ANTI-TUMOR IMMUNITY |
| 摘要 |
β-mannosylceramides or salts or solvates thereof in a pharmaceutically acceptable carrier, for use as a Type I NKT cell agonist in conjunction with a therapeutically effective amount of α-galactosylceramide or a salt or a solvate thereof, and/or at least one or more T-cell co-stimulatory molecules, disclosed. Compositions comprising β-mannosylceramide, as well as methods of treatment of tumors are also provided. |
| 申请公布号 |
US2014348786(A1) |
申请公布日期 |
2014.11.27 |
| 申请号 |
US201414453829 |
申请日期 |
2014.08.07 |
| 申请人 |
The United States of America,as represented by the secretary, Department of Health and Human Service ;The University of Birmingham, of Edgbaston |
发明人 |
Berzofsky Jay A.;O'Konek Jessica J.;Terabe Masaki;Illarionov Petr A.;Besra Gurdyal S. |
| 分类号 |
A61K39/00;C07H15/04;A61K45/06 |
主分类号 |
A61K39/00 |
| 代理机构 |
|
代理人 |
|
| 主权项 |
1. A composition comprising a β-mannosylceramide (β-ManCer) or salt or solvate thereof in a pharmaceutically acceptable carrier, wherein the β-ManCer comprises:
a) a sphingosine moiety; and b) a fatty acid moiety comprising a linear or branched, saturated or unsaturated, aliphatic hydrocarbon group having from about 8 to about 49 carbon atoms. |
| 地址 |
Bethesda MD US |
