| 发明名称 |
NEUTRALISING ANTIBODIES TO THE MAJOR EXOTOXINS TCDA AND TCDB OF CLOSTRIDIUM DIFFICILE |
| 摘要 |
This present invention describes the derivation and selection of antibodies capable of neutralising the major exotoxins; TcdA and TcdB of Clostridium difficile. The invention also describes novel neutralisation and antigen binding properties of individual Mabs and mixtures thereof. |
| 申请公布号 |
US2014348844(A1) |
申请公布日期 |
2014.11.27 |
| 申请号 |
US201214344637 |
申请日期 |
2012.09.10 |
| 申请人 |
Humphreys David Paul;Lightwood Daniel John;Tyson Kerry Louise;Knight David Edward Ormonde;Hervé Karine Jeannine Madeleine;Compson Joanne Elizabeth;Page Matthew Jon Timothy;Payne Andrew Charles;Fisher Nicola Louise;Mackenze Brendon;Cox Matthew |
发明人 |
Humphreys David Paul;Lightwood Daniel John;Tyson Kerry Louise;Knight David Edward Ormonde;Hervé Karine Jeannine Madeleine;Compson Joanne Elizabeth;Page Matthew Jon Timothy;Payne Andrew Charles;Fisher Nicola Louise;Mackenze Brendon;Cox Matthew |
| 分类号 |
C07K16/12;G01N33/573;G01N33/68;G01N33/569;A61K39/40;A61K45/06 |
主分类号 |
C07K16/12 |
| 代理机构 |
|
代理人 |
|
| 主权项 |
1. A monoclonal antibody specific to antigen TcdA or TcdB, wherein the antibody has high affinity for the target antigen and is suitable for reducing the duration and/or severity of diarrhoea, morbidity and/or mortality in a patient with Clostridium difficile infection or at risk of said infection. |
| 地址 |
Slough GB |
