METHOD FOR SCREENING DRUGS FOR TREATING/PREVENTING MYELODYSPLASTIC SYNDROME, ETC.

摘要

The present invention provides a method, etc. for screening drugs for treating or preventing acute myelogenous leukemia or myelodysplastic syndrome, the method comprising: (a) a process for causing hematopoietic precursor cells, induced from induced pluripotent stem (iPS) cells produced from non-T cells in blood mononuclear cells isolated from a myelodysplastic syndrome patient, to form colonies in the presence and absence of the test substance; and (b) a process for comparing the number of colonies in the presence of the test substance with the number of colonies in the absence of the test substance and when there is an increase, for selecting the test substance as a candidate for a drug to treat or prevent acute myelogenous leukemia or myelodysplastic syndrome.