发明名称 |
GENETIC SIGNATURE OF VULNERABILITY TO INHIBITORS OF BASE EXCISION REPAIR (BER) IN CANCER |
摘要 |
The invention relates to the identification of genetic signatures and expression profiles that are a part of the Base Excision Repair (BER) pathway, a major DNA repair pathway that modifies base lesions. In one embodiment, the present invention provides a method of determining responsiveness of treatment by BER inhibitors for malignant glioma by determining the presence of a low level of expression of Apex 1, a low level of expression of Apex 2, and a high level of expression of MPG. |
申请公布号 |
CA2912786(A1) |
申请公布日期 |
2014.11.27 |
申请号 |
CA20142912786 |
申请日期 |
2014.05.21 |
申请人 |
DIGNITY HEALTH;THE TRANSLATIONAL GENOMICS RESEARCH INSTITUTE |
发明人 |
MEHTA, SHWETAL V.;BERENS, MICHAEL E.;DHRUV, HARSHIL DINESHKUMAR |
分类号 |
C12Q1/68 |
主分类号 |
C12Q1/68 |
代理机构 |
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地址 |
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