发明名称 |
Novel Process for the Preparation of Intermediates of HMG-CoA Reductase Inhibitors |
摘要 |
The present invention relates to an improved process for the preparation of compound of Formula-II, which is an intermediate in the preparation of HMG-CoA reductase inhibitors.;;wherein X is hydrogen or hydroxy protecting group and R1 is carboxyl protecting group. |
申请公布号 |
US2014349350(A1) |
申请公布日期 |
2014.11.27 |
申请号 |
US201414288999 |
申请日期 |
2014.05.28 |
申请人 |
Mylan Laboratories LTD |
发明人 |
Van Vliet Michiel Christian Alexander;Schoevaart Willem Robert Klass;Sethi Madhuresh Kumar;Mahajan Sanjay;Mara Bhairaiah |
分类号 |
C12P17/12;C12P13/02;C12P9/00 |
主分类号 |
C12P17/12 |
代理机构 |
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代理人 |
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主权项 |
1. A process for the preparation of compound of Formula-II comprising the steps of:
a) enzymatic enantioselective amidation of compound of Formula-III in presence of suitable enzyme to get amide compound of Formula-IV wherein R2 is C1-C5 alkyl or aryl or arylalkyl group; b) transesterification of compound of Formula-IV into compound of Formula-V wherein R3 is C1-C5 alkyl or aryl or arylalkyl group with proviso that R3 is different than R2 of Formula-IV; c) protecting the hydroxy group with suitable hydroxy protecting group to get compound of Formula-VI wherein X is a suitable protecting group; d) converting the compound of Formula-VI into compound of Formula-VII; and e) converting compound of Formula-VII into compound of Formula-II wherein R1 is carboxyl protecting group and X is defined above. |
地址 |
Hyderabad IN |