| 摘要 |
The present invention relates to a polypeptide that drives T cell proliferation and differentiation, and methods and agents for modulating the expression and/or function of the polypeptide. Agents that up regulate the expression and/or function of the polypeptide are useful in the treatment or prevention of diseases and disorders that would benefit from stimulation of T cell proliferation and/or differentiation, such as cancer and chronic viral infections. Agents that down-regulate the expression and/or function of the polypeptide are useful in the treatment or prevention of diseases, disorders and conditions involving unwanted or excessive proliferation and/or differentiation of T cells, such as autoimmune and inflammatory diseases. The invention also provides isolated T cells containing an expression vector encoding a polypeptide of the invention. Such T cells may be used in adoptive cell transfer therapies. |
