CO-IMMUNIZATION WITH ATTENUATED RABIES VIRUS AND NON-RABIES ANTIGEN

摘要

Provided is a method of enhancing an antigen-induced long-lasting immune response in a host comprising administering to a host an effective amount of: (a) a nonpathogenic recombinant rabies virus comprising at least three copies of a mutated G gene, wherein said mutated G gene encodes a rabies virus glycoprotein wherein the glycoprotein amino acid 194 is serine and the glycoprotein amino acid 333 is glutamic acid, wherein said recombinant rabies virus does not express a foreign protein antigen; and (b) a non-rabies antigen that is not expressed by the rabies virus. Also provided are related compositions, kits and vaccines.