| 主权项 |
1. A compound of formula I or pharmaceutically acceptable salts thereof: R1 is a heteroaryl selected from isoxazolyl, pyrazolyl, imidazolyl, oxazolyl, thiazolyl, pyridinyl, pyradizinyl, and pyrimidinyl; R2 and R3 are each independently chosen from hydrogen, hydroxy, —OR, —OCOR, —OCOOR, —OCONHR, and C1-6alkyl; X is selected from —(C0-3alkyl)PO(R′)OR, —(C0-3 alkyl)PO(OR)2, —(C0-3alkyl)PO(NRR)2, —SO3R,
—(C0-3 alkyl)PO(C1-10alkyl)OR, —(C0-3 alkyl)PO(C3-10cycloalkyl)OR,(C0-3alkyl)PO(H)OR, —(C0-3alkyl)PO(NHCR′R″COOR)2 and —COOR; R is independently selected from hydrogen, C1-10 alkyl, —C1-5 alkylaryl, —CR′R′—OCO—C1-10 alkyl, and —CR′R′—OCO—O—C1-10 alkyl; R′ and R″ are independently selected from hydrogen and C1-10 alkyl; L is chosen from a bond, —CONR4—, —NR4CO—, aryl, and heteroaryl; D is chosen from a bond, aryl, and heteroaryl, provided that when L is a bond then D is aryl or heteroaryl; R4, R6, and R7 are each independently selected from
hydrogen,halogen,carboxyl C0-10 alkyl,C1-10 alkyl,C2-10 alkenyl,C2-10 alkynyl,C1-10 alkenylamino,C1-10 alkyl(oxy)0-1 carbonylC1-10 alkyl,aryl C0-10 alkyl(oxy)0-1 carbonylC1-10 alkyl,C3-8 cycloalkyl C0-10 alkyl(oxy)0-1carbonyl C1-10 alkyl,(C3-8)heterocyclyl C0-10 alkyl(oxy)0-1 carbonyl C1-10 alkyl,(C3-8)heterocycloalkyl C0-10 alkyl(oxy)0-1 carbonyl C1-10 alkyl,aryl(oxy)0-1C0-10 alkyl,C3-8 cycloalkyl(oxy)0-1 C0-10 alkyl,C3-8 heterocyclyl(oxy)0-1 C0-10 alkyl,C3-8 heterocycloalkyl (oxy)0-1C0-10 alkyl,C1-10 alkoxyl,arylC1-10 alkoxyl, andhydroxyC0-10alkyl; wherein R1, R2, R3, R4, R6, R7, and D are optionally substituted with 1, 2, or 3 substituent R5 chosen from:
halogen,(carbonyl)0-1C1-10 alkyl,(carbonyl)0-1C2-10 alkenyl,(carbonyl)0-1 C2-10 alkynyl,C1-10 alkylcarbonyl,C2-10 alkenylcarbonyl,C2-10 alkynylcarbonyl,aryl C0-10 alkyl,(C3-8)heterocyclyl C0-10 alkyl,C3-8 cycloalkyl C0-10 alkyl,(C3-8)heterocycloalkyl C0-10 alkyl,C1-4acylamino C0-10 alkyl,C0-10 alkylamino C0-10 alkyl,arylC0-10 alkylamino C0-10 alkyl,C3-8 cycloalkyl C0-10 alkylamino C0-10 alkyl,C3-8 heterocyclyl C0-10 alkylamino C0-10 alkyl,C3-8 heterocycloalkyl C0-10 alkylamino C0-10 alkyl,C1-10alkyloxy C0-10alkyl,(C1-10 alkyl)2aminocarbonyloxy,hydroxy C0-10alkyl,C1-10 alkylsulfonyl,C1-10 alkylsulfonylamino,aryl C1-10 alkylsulfonylamino,C3-8 heterocyclyl C1-10 alkylsulfonylamino,C3-8 heterocycloalkyl C1-10 alkylsulfonylamino,C3-8 cycloalkyl C1-10 alkylsulfonylamino,cyano,nitro,perfluoroC1-6alkyl, andperfluoroC1-6alkoxy; wherein R5 is optionally substituted with 1, 2, or 3 substituents chosen from hydrogen, hydroxy, (C1-6)alkoxyl, halogen, CO2H, CN, O(C═O)C1-C6 alkyl, NO2, trifluoromethoxy, trifluoroethoxy, —O(0-1)(C1-10)perfluoroalkyl, and NH2; and provided that when X is —COOR then L is isoxazoldiyl and D is phenyl. |
