METHODS OF TREATING OR PREVENTING INSULIN RESISTANCE AND ASSOCIATED DISEASES AND CONDITIONS

摘要

Disclosed are methods of treating an animal for insulin resistance and associated diseases or conditions, activating the transcriptional activity of heat shock factor 1 (HSF1), or inducing the expression of heat shock protein 70 (HSP70) in an animal in need thereof, wherein the methods involve administering an effective amount of one or more compounds of formula (I) or an epimer thereof, wherein Ar, and R1-R6 are described herein. Examples of diseases or conditions associated with insulin resistance include diabetes, obesity, inflammation, metabolic syndrome, polycystic ovary disease, arteriosclerosis, non-alcoholic fatty liver disease, reproductive abnormality in a female, and growth abnormality.;

主权项

1. A method of treating an animal for a disease or condition associated with insulin resistance comprising administering to the animal an effective amount of a compound of formula (I):or an epimer thereof; wherein
Ar is an aryl group, optionally substituted with one or more substituents selected from the group consisting of C1-C6 alkyl, C1-C6 hydroxyalkyl, C1-C6 alkoxy, halo, and nitro; X is O, NH, or S; R2 and R3 are independently C1-C6 alkyl; R1 is isopropyl or isopropylenyl; “a” is a single bond or a double bond;
when “a” is a double bond, R4 is hydrogen, and R5 is halo or H;when “a” is a single bond, R4 is selected from the group consisting of halo, hydroxy, and C1-C6 alkoxy and R5 is halo or H; and R6 is H, C1-C6 alkyl carbonyl, or hydroxy C1-C6 alkyl carbonyl.