发明名称 |
METHOD FOR PREPARING ANDROGEN RECEPTOR ACTIVITY-DEPENDENT BREAST CANCER CELL LINE, SCREENING METHOD USING CELL LINE, AND METHOD, KIT AND MARKER FOR DETERMINING ACQUISITION OF ANDROGEN RECEPTOR ACTIVITY DEPENDENCE IN BREAST CANCER PATIENT |
摘要 |
<p>The present invention addresses the problem of providing a cell line having a novel resistance mechanism that is completely different from the resistance mechanisms in conventional hormone therapy, a screening method using the cell line, and a method for determining whether or not a breast cancer patient has acquired the aforesaid resistance mechanism. Provided are: a method for preparing androgen receptor activity-dependent breast cancer cells, said method comprising a step for culturing T47D-TE8 cells in an estrogen-depleted medium in the presence of androgen; a screening method using the breast cancer cells; and a method and a kit for determining the presence or absence of the acquisition of androgen receptor activity dependence in a breast cancer patient with the use of at least one member selected from the group consisting of KLK3, DDC and AR as an indicator.</p> |
申请公布号 |
WO2014188775(A1) |
申请公布日期 |
2014.11.27 |
申请号 |
WO2014JP58262 |
申请日期 |
2014.03.25 |
申请人 |
TOHOKU UNIVERSITY |
发明人 |
HAYASHI, SHIN-ICHI;FUJII, RIKA |
分类号 |
C12Q1/04;A61K35/00;A61K45/00;C07K14/72;C12N5/09;C12N15/09;C12Q1/68;G01N33/15;G01N33/50;G01N33/68 |
主分类号 |
C12Q1/04 |
代理机构 |
|
代理人 |
|
主权项 |
|
地址 |
|