| 摘要 |
<p>The present invention relates to a polysaccharide extracted from honeysuckle, preparation method and use thereof in preparing medicines for treating Alzheimer's disease (AD). Specifically, the present application relates to anα-1,4-glucan extracted from honeysuckle; the preparation method comprising: extracting crude polysaccharide from honeysuckle at first, and then performing ethanol precipitation, deproteinization and multiple types of column chromatography purification to obtain theα-1,4-glucan. Experiments in vitro prove that theα-1,4-glucan is capable of significantly inhibiting the aggregation of a critical pathogenic factor Aβ42 of AD and also inhibiting Aβ42-aggregation-induced neural cytotoxicity, thus theα-1,4-glucan is expected to be a potential polysaccharide medicine for the treatment of AD.</p> |
