DIAGNOSTIC ASSAY TO PREDICT CARDIOVASCULAR RISK

摘要

This invention relates to the area of cardiovascular disorders and specifically relates to methods of diagnostic tests using a combination of markers to predict an individual's risk for developing coronary artery disease (CAD) and related diseases, such as angina pectoris and peripheral vascular disease and, more particularly, to determine an individual's risk of myocardial infarction, death, and stroke. Exemplary biomarkers include C-reactive protein (CRP), fibrin degradation products (FDPs), Heat Shock Protein 70 (HSP70), and/or anti-CMV antibody.

主权项

1. A method of determining risk of an adverse cardiovascular outcome in a subject, the method comprising: measuring the level of each of a plurality of biomarkers in a test biological sample obtained from the subject, wherein:
the plurality of biomarkers comprises (i) a fibrin and fibrinogen degradation product (FDP) marker, wherein the FDP marker includes a mixture of at least two fibrin and fibrinogen degradation products (FDPs) selected from the group consisting of fragment D, fragment E, D-dimer, fragment X, fragment Y, and an initial plasmin digest product (IPDP), and (ii) at least one inflammation biomarker, autoimmune disease biomarker, or cellular stress biomarker; and the levels of the plurality of biomarkers indicate a risk of an adverse cardiovascular outcome in the subject.