| 发明名称 |
HISTIDYL-TRNA SYNTHETASE-FC CONJUGATES |
| 摘要 |
The present invention provides histidyl-tRNA synthetase and Fc region conjugate polypeptides (HRS-Fc conjugates), such as HRS-Fc fusion polypeptides, compositions comprising the same, and methods of using such conjugates and compositions for treating or diagnosing a variety of conditions. The HRS-Fc conjugates of the invention have improved controlled release properties, stability, half-life, and other pharmacokinetic and biological properties relative to corresponding, unmodified HRS polypeptides. |
| 申请公布号 |
US2014349369(A1) |
申请公布日期 |
2014.11.27 |
| 申请号 |
US201414214491 |
申请日期 |
2014.03.14 |
| 申请人 |
aTyr Pharma Inc. |
发明人 |
Buechler Ying;Chiang Kyle;Do Minh-Ha;Lee Darin;Piehl Kristi;Thomas Marc;Watkins Jeffry D.;Wu Chi-Fang;Mendlein John D. |
| 分类号 |
C12N9/00 |
主分类号 |
C12N9/00 |
| 代理机构 |
|
代理人 |
|
| 主权项 |
1. A histidyl-tRNA synthetase (HRS) fusion polypeptide, comprising (a) an HRS polypeptide that comprises amino acid sequence at least 80% identical to any of SEQ ID NOS:1-106, 170-181, or 185-191 or a sequence of any of Tables D1, D3-D6, or D8, and (b) at least one Fc region fused to the C-terminus, the N-terminus, or both of the HRS polypeptide. |
| 地址 |
San Diego CA US |
