发明名称 POTENT NON-UREA INHIBITORS OF SOLUBLE EPOXIDE HYDROLASE
摘要 The present invention relates to compounds that exhibit vasodilatory and anti-inflammatory effects by inhibiting the activity of soluble epoxide hydrolase (sEH). The present invention is also directed to methods of identifying such compounds, and use of such compounds for the treatment of diseases related to dysfunction of vasodilation, inflammation, and/or endothelial cells. In particular non-limiting embodiments, components of the invention may be used to treat hypertension.
申请公布号 US2014349368(A1) 申请公布日期 2014.11.27
申请号 US201414182175 申请日期 2014.02.17
申请人 THE TRUSTEES OF COLUMBIA UNIVERSITY IN THE CITY OF NEW YORK 发明人 Landry Donald W.;Xie Yuli;Lu Yidong;Gong Gangli;Deng Shi-Xian;Rinderspacher Kirsten Alison
分类号 C12N9/99;C07F9/59;C07D409/12;C07D211/62;C07D211/96;C07D401/12 主分类号 C12N9/99
代理机构 代理人
主权项 1. A compound of Formula 1: wherein R1 and R2 are independently selected for each occurrence from the group consisting of Phosphorus, substituted or unsubstituted benzothiazol, substituted or unsubstituted pyridyl, substituted or unsubstituted naphthyl, substituted or unsubstituted phenyl, substituted or unsubstituted alkyl, substituted or unsubstituted cycloalkyl, substituted or unsubstituted aryl, substituted or unsubstituted cycloalkalkyl, substituted or unsubstituted arylalkyl, substituted or unsubstituted heteroarylalkyl, substituted or unsubstituted heteroaryl, substituted or unsubstituted heterocyclic, —C(O)R3 and —S(O)2R3; wherein R3 is independently selected for each occurrence from the groups consisting of substituted or unsubstituted alkyl, substituted or unsubstituted cycloalkyl; substituted or unsubstituted aryl; substituted or unsubstituted arylalkyl; substituted or unsubstituted heteroaryl; substituted or unsubstituted heterocyclic, substituted or unsubstituted naphthyl, substituted or unsubstituted phenyl, substituted or unsubstituted thienyl, substituted or unsubstituted benzothienyl, substituted or unsubstituted pyridyl, substituted or unsubstituted indol, substituted or unsubstituted isoquinolyl, substituted or unsubstituted quinolyl, and substituted or unsubstituted benzothiazol; and further wherein, when R2 isand R1 is a substituted phenyl, wherein the substituent is an unsubstituted alkyl, the alkyl is at least a C3 alkyl; and pharmaceutically acceptable salts and prodrugs thereof.
地址 New York NY US
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