发明名称 |
ANILINE DERIVATIVES, THEIR PREPARATION AND THEIR THERAPEUTIC APPLICATION |
摘要 |
The present invention relates to aniline derivatives of formula (I), to their preparation and to their therapeutic application, for example in treating glaucoma: Formula (I), R1a represents H, an halogen, a (C1-C6)alkyl or a CN; R1b represents H, an halogen or a (C1-C6)alkyl; R1c represents H or a (C1-C6)alkyl; R2 represents H, an halogen, an OH, an O—(C1-C6)alkyl or (C1-C6)alkyl; R3 represents H, an halogen, a (C1-C6)alkyl, an OH, an O—(C1-C6)alkyl, a CONH2 or CN; R4 represents H, an halogen or a (C1-C6)alkyl; R5 represents H or F: R7 represents H or F; R8 represents H or F; R9 represents H or (C1-C6)alkyl, or one of its enantiomers.; |
申请公布号 |
US2014350019(A1) |
申请公布日期 |
2014.11.27 |
申请号 |
US201214344925 |
申请日期 |
2012.09.07 |
申请人 |
Feutrill John;Leriche Caroline;Middlemiss David |
发明人 |
Feutrill John;Leriche Caroline;Middlemiss David |
分类号 |
C07C217/84;C07C255/57;C07C215/76;C07C255/58;C07C237/30;C07D295/088;C07C235/20;C07C213/02;C07C213/08;C07C253/30;A61K45/06;A61K31/196;A61K31/277;A61K31/216;A61K31/5375;A61K31/165;C07C63/72 |
主分类号 |
C07C217/84 |
代理机构 |
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代理人 |
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主权项 |
1. A compound of formula (I), or one of its prodrugs, in which: R1a represents H, an halogen, a (C1-C6)alkyl or a CN; R1b represents H, an halogen or a (C1-C6)alkyl; R1c represents H or a (C1-C6)alkyl; R2 represents H, an halogen, an OH, an O—(C1-C6)alkyl or a (C1-C6)alkyl; R3 represents H, an halogen, a (C1-C6)alkyl, an OH, an O—(C1-C6)alkyl, a CONH2 or a CN; R4 represents H, an halogen or a (C1-C6)alkyl; R5 represents H or F; R7 represents H or F; R8 represents H or F; R9 represents H or a (C1-C6)alkyl, or an entaniomer thereof. |
地址 |
Rosanna AU |