USE OF COMPLEX FORMS OF CALMODULIN-LIKE SKIN PROTEIN CLSP

摘要

The invention also relates to the use of these complex forms for the purposes of screening for biological or chemical compounds capable of modulating a biological activity of said complex forms and/or for preparing and/or improving a pluristratified cell model.

主权项

1. A method of screening for anti-ageing active agents, comprising:
a) bringing at least one cell type containing at least one complex form of calmodulin-like skin protein, or CLSP, which derives at least in part from a polypeptide having an amino acid sequence encoded by a nucleic acid sequence represented completely or partly by SEQ ID NO 1 or an analogue thereof, or a fragment thereof, into contact with at least one test anti-ageing active agent, under conditions suitable for the expression of said complex form, b) determining a content of said complex form, and c) comparing said content determined in step b) with a content of said complex form determined in the absence of test chemical or biological compound.