COMPOSITIONS, METHODS AND USES FOR ALPHA-1 ANTITRYPSIN FUSION MOLECULES

摘要

Compositions of and methods for making and using alpha-1 antitrypsin (AAT) fusion molecules or peptide derivatives thereof are disclosed. The compositions and methods relate to generating an AAT fusion molecule of use in pharmaceutically acceptable compositions to treat a subject in need of AAT therapy or treatment. Compositions and methods disclosed herein concern linking AAT or derivative thereof to an immune fragment.

主权项

1. A construct comprising:
a nucleic acid encoding alpha-1 antitrypsin (AAT) or fragment or peptide cleavage molecule thereof; and a nucleic acid encoding an immune fragment or a fragment capable of being joined to itself, the nucleic acid further manipulated to truncate or eliminate the immune fragment hinge region.